Regeneration is the reproduction or reconstitution of a lost or injured part to its original state. In the body, regeneration takes place as part of the natural healing process as cells undergo mitosis to repair or replace the cells damaged or lost due to injury or pathology. By following the genetic instructions held in the cells’ DNA, the body is able to regenerate many types of damaged tissues and bone to restore function. In dentistry, advances are being made that may allow for regenerative therapies that guide the body to replace or repair the oral tissues and structures without the need for implants and prostheses. Such regeneration may take place due to the introduction of a patient’s stem cells, the placement of bioactive scaffolds, and the triggering of growth factors. Dental regeneration procedures have seen success in encouraging partial regeneration though whole tooth regeneration is not yet possible.