An acellular dermal allograft is a soft tissue allograft developed from donated human tissue, which is typically obtained by dental professionals for use in procedures from tissue banks. The native framework of the allograft is maintained, allowing it to be used in a wide variety of applications beyond oral and periodontal surgery, including in cosmetic surgery procedures like lip augmentation and to treat moderate to severe burns. An acellular dermal allograft is extremely safe and effective when building soft tissue, but in rare cases, complications can occur as with any medical procedure. In studies, the only complication recorded was infection, which was treated with antibiotics and did not require graft extrusion. Minimal postoperative pain and swelling was noted, as well as the absence of immunogenicity. Acellular dermal allografts are a viable solution for the treatment of soft tissue deficits and to augment soft tissue where needed for structural or aesthetic purposes.